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Developing a Searchable PICO(T) Question for Clinical Inquiry

Developing a Searchable PICO(T) Question for Clinical Inquiry

Responding to Kimberly

Hi Kimberly,

This is a very insightful post! Your comprehensive exploration of the clinical issue surrounding treatment-resistant major depressive disorder (TRMDD) and suicidal ideation (SI) demonstrates a commendable commitment to understanding the gravity of the situation. The statistics from the CDC emphasize the urgent need for effective interventions, and your strategic approach to article search is meticulous.

I concur with your emphasis on the ethical dimension of addressing TRMDD and SI as a mass concern for medical management. However, while ketamine has shown promise in some studies, it’s crucial to consider the broader context and potential ethical implications of its use (Lapidos et al., 2023). Additionally, your proposed future strategies for database searches are apt, but ensuring a nuanced evaluation of outcomes, risks, and patient profiles should remain a priority. Overall, your diligence in research and ethical considerations is evident, and I appreciate your dedication to finding viable solutions for such a pressing public health issue.


Lapidos, A., Lopez-Vives, D., Sera, C. E., Ahearn, E., Vest, E., Senic, I., Vande Voort, J. L., Frye, M., Goes, F. S., Achtyes, E., Greden, J., & Parikh, S. V. (2023). Patients’ recovery and non-recovery narratives after intravenous ketamine for treatment-resistant depression. Journal of Affective Disorders, 323, 534–539.

Responding to Anna Cooper

Hi Anna,

This is a great post! Your detailed exploration of the insulin cost issue is commendable. The statistics you provided effectively highlight the magnitude of the problem, emphasizing the urgency of finding solutions. Your approach to filtering search results for scholarly and recent publications demonstrates a commitment to academic rigor.

I agree with your consideration of pharmacy benefit managers as potential culprits in insulin price manipulation (Knox, 2020). This aligns with existing literature pointing to their role in exacerbating the issue. To enhance your analysis, consider delving deeper into specific case studies or policy implications that address the actions of pharmacy benefit managers. Additionally, incorporating patient perspectives and the impact on healthcare disparities could provide a more comprehensive understanding of the issue.

Furthermore, expanding your search to international perspectives may offer insights into successful strategies employed in other countries to control insulin costs. Collaborating with healthcare economists or policy experts could also enrich your discussion. Overall, your groundwork is solid, and further exploration along these lines could strengthen the depth and breadth of your research.


Knox, R. (2020). Insulin insulated: barriers to competition and affordability in the United States insulin market. Journal of Law and the Biosciences, 7(1).


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In this Discussion, you will transform a clinical inquiry into a searchable question in PICO(T) format so you can search the electronic databases more effectively and efficiently. You will share this PICO(T) question and examine strategies you might use to increase the rigor and effectiveness of a database search on your PICO(T) question.

Developing a Searchable PICO(T) Question for Clinical Inquiry

Developing a Searchable PICO(T) Question for Clinical Inquiry

To Prepare:

Review the Resources and identify a clinical issue of interest that can form the basis of a clinical inquiry.
Review the materials offering guidance on using databases, performing keyword searches, and developing PICO(T) questions provided in the Resources.
Based on the clinical issue of interest and using keywords related to the clinical issue of interest, search at least two different databases in the Walden Library to identify at least four relevant peer-reviewed articles related to your clinical issue of interest. You should not be using systematic reviews for this assignment; select original research articles.
Review the Resources for guidance and develop a PICO(T) question of interest to you for further study. It is suggested that an Intervention-type PICOT question be developed as these seem to work best for this course.
*Library tip:

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