Alzheimer’s Disease – Insights into Pathology, Molecular Mechanisms, and Therapy

Alzheimer’s Disease – Insights into Pathology, Molecular Mechanisms, and Therapy

The article aims at describing Alzheimer’s disease, which is a progressive neurocognitive disorder affecting patients’ memory and other cognitive skills. It outlines the progressive stages of the disease that start with mild problems with memory and worsen the inability to talk and perform other essential tasks. The article also reviews the critical risk factors for developing Alzheimer’s disease with emphasis on age, genetic susceptibility, and lifestyle factors (Zheng & Wang, 2024). Symptom management and the utilization of strategies that could halt the progression of the illness require identification at an early stage. Altogether, the article makes it clear that more research needs to be done to determine more factors that cause Alzheimer’s and what treatments could be effective.

This paper explores the diagnostic methods used to diagnose Alzheimer’s disease with a focus on structural and functional changes through brain Magnetic Resonance Imaging and Positron Emission Tomography scans. It emphasizes the neuropsychological assessments that determine cognitive areas such as memory, language and the ability to solve problems. This is followed by an emphasis on distinguishing Alzheimer’s disease from other dementias with an underlying goal of providing an accurate diagnosis as well as a corresponding treatment plan. As stated by Zhang et al. (2024), medications and behavioral therapies are pivotal for the clinical treatment of the condition and better quality of life in the patients. The article emphasizes the fact that early treatment should be done immediately as it increases the efficacy of the treatment process and that it may also help to prevent further deterioration of patients with Alzheimer’s disease.

Finally, the current research activities that focus on finding improved strategies to manage or treat Alzheimer’s disease are discussed. It focuses on disease-modifying therapies, such as experimental medications for amyloid plaques and tau tangles. Also, it highlights the potentiality of lifestyle modifications like exercise, mental stimulation, and dietary changes to prevent disease progression. The article also mentions the difficulties of caregivers and the importance of the support and help that they need. Lastly, it emphasizes the need to conduct research regarding the treatment of the disease further and to increase people’s awareness so as to be able to provide better care to patients who have Alzheimer’s disease.

References

Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024). Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduction and Targeted Therapy, 9(1). https://doi.org/10.1038/s41392-024-01911-3

Zheng, Q., & Wang, X. (2024). Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy. Protein & Cell, 16(2). https://doi.org/10.1093/procel/pwae026

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Recent or current article or resource related to a neurocognitive disorder. Summarize your article or resource. If you are using direct quotes, be sure to do so according to APA 7 formatting. If you include additional information about your topic that is not included in your article or resource, you are required to cite the source where you found that information using APA 7 formatting.
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Alzheimer’s Disease

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